沈杰,男,36歲,南開大學(xué)藥學(xué)院副教授。[1]

人物經(jīng)歷

1992-1996中國科學(xué)技術(shù)大學(xué) 化學(xué)物理系 本科

1997-2000中國科學(xué)技術(shù)大學(xué) 化學(xué)系 碩士

2000-2002美國Wayne State University,博士(轉(zhuǎn)學(xué))

2002-2007美國The Ohio State University,化學(xué)博士

2007-2008 美國The Ohio State University,博士后

2009-至今南開大學(xué)藥學(xué)院 副教授

其他作品

主要研究對象:抗癌類藥物的合成和設(shè)計;所研究過的藥物分子包括:rebeccamycin analogs,anthracycline analogs,HDACi,geldanamycin analogs 和GST-targeting drugs

發(fā)表論文
1 Shen, J.; Woodward, R.; Kedenburg, J. P.; Liu, X.; Chen, M. Histone Deacetylase Inhibitor through Click Chemistry. J. Med. Chem. 2008, 51(23), 7417-7427.
2 Li, M.; Shen, J.; Liu, X.; Shao, J.; Yi, W.; Chow, C. S.; Wang, P. G. Identification of a New a 1,2-Fucosyltransferase Involved in O-Antigen Biosynthesis of Escherichia coli O86:B7 and Formation of H-Type 3 Blood Group Antigen. Biochemistry, 2008,47(44), 11590-11597。
3 Yi, W.; Shen, J.; Zhou, G.; Li, J.; Wang, P. G. Bacterial Homologue of Human Blood Group A Transferase. Journal of the American Chemical Society 2008, 130(44), 14420-14421.
4 Li, M.; Liu, X.; Shao, J.; Shen, J.; Jia, Q.; Yi, W.; Song, J. K.; Woodward, R.; Chow, C. S.; Wang, P. G. Characterization of a Novel a 1,2-Fucosyltransferase of Escherichia coli O128:B12 and Functional Investigation of Its Common Motif. Biochemistry, 2008, 47(1), 378-387.
5 Cui, H.; Shen, J.; Lu, D.; Zhang, T.; Zhang, W.; Sun, D.; Wang, P. G. 4-Aryl-1,3,2-oxathiazolylium-5-olate: a novel GST inhibitor to release JNK and activate c-Jun for cancer therapy. Cancer Chemotherapy and Pharmacology, 2008, 62(3), 509-515.
6 Battisti RF, Zhong Y, Fang L, Gibbs S, Shen J, Nadas J, Zhang G, Sun D. “Modifying the Sugar Moieties of Daunorubicin Overcomes P-gp-Mediated Multidrug Resistance”. Molecular Pharmaceutics, 2007, 4,140-153.
展開表格申請專利
點擊化學(xué)合成具有分支結(jié)構(gòu)的組蛋白去乙酰化酶抑制劑,王鵬,沈杰,尹正.