張海林（河北醫(yī)科大學(xué)醫(yī)學(xué)與健康研究院院長(zhǎng)）

人物經(jīng)歷

1987-1991年在河北醫(yī)科大學(xué)藥理教研室工作，任助教、講師。

1996-1997年6月在英國(guó)倫敦大學(xué)做博士后，1997年6月-2001年10月在美國(guó)紐約大學(xué)西奈山醫(yī)學(xué)中心做博士后，任職。

2002年受聘河北醫(yī)科大學(xué)特聘教授，任藥理教研室教授、博士生導(dǎo)師，藥理教研室副主任，基礎(chǔ)醫(yī)學(xué)研究所藥理研究室主任。

2003-2010任藥學(xué)院副院長(zhǎng)。

2007年起任藥理教研室主任。

2010年起任基礎(chǔ)醫(yī)學(xué)院院長(zhǎng)，基礎(chǔ)醫(yī)學(xué)研究所所長(zhǎng)。

2012年12月，任河北醫(yī)科大學(xué)副校長(zhǎng)。^[2]

社會(huì)任職

中國(guó)神經(jīng)科學(xué)學(xué)會(huì)常務(wù)理事，曾任中國(guó)藥理學(xué)會(huì)、中國(guó)細(xì)胞生物學(xué)會(huì)理事；曾任河北省神經(jīng)科學(xué)學(xué)會(huì)理事長(zhǎng)，現(xiàn)任河北省藥理學(xué)會(huì)理事長(zhǎng)?！禞 Gen Physiol》、《Channels》編委；《神經(jīng)藥理學(xué)》、副主編；《中國(guó)藥學(xué)》（英文版）、《中國(guó)藥理學(xué)通報(bào)》編委。^[3]

主要成就

主持國(guó)家自然科學(xué)基金杰出青年科學(xué)基金項(xiàng)目、重點(diǎn)項(xiàng)目、面上項(xiàng)目、國(guó)際合作項(xiàng)目；國(guó)家973課題、國(guó)家863計(jì)劃；美國(guó)國(guó)家衛(wèi)生研究院（NIH）國(guó)際合作基金項(xiàng)目、科技部重大基礎(chǔ)研究前期研究專(zhuān)項(xiàng)等。在國(guó)際高水平的學(xué)術(shù)雜志《Nature Cell Biology》《Neuron》《J Clin Invest》等發(fā)表SCI論文100多篇；研究成果獲河北省自然科學(xué)一等獎(jiǎng)，河北省科學(xué)技術(shù)一等獎(jiǎng)。^[3]

藥理學(xué)、神經(jīng)科學(xué)，重點(diǎn)關(guān)注神經(jīng)元興奮性的離子通道機(jī)制及相關(guān)疾病、相關(guān)藥物靶點(diǎn)研究。^[3]

1. Peng LY, Mirshahi T., Zhang HL., Hirsch J. and Logothetis DE (2003) Critical Determinants of the G Protein g Subunits in the Gbg Stimulation of G Protein-actiated Inwardly Rectifying Potassium (GIRK) Channel Actiity. J Biol Chem 278 (50), 50203–50211,
2. Chan KW, Zhang HL and Logothetis1 DL (2003) N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. The EMBO Journal, 22 (15) 3833-3843
3. Zhang H., Craciun LC, Mirshahi T, Rohács T, Lopes CMB, Jin T, and Logothetis DE. (2003) PIP2 Actiates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents. Neuron， 37（6）, 963-975
4. Lopes C M.B., Zhang H., Rohacs T, Jin T, Yang, J. and Logothetis D.E. (2002) Alterations in Consered Kir Channel-PIP2 Interactions Underlie Channelopathies. Neuron, 34, 933–944
5. Perez CA., Huang L., Rong M., Kozak JA., Zhang H., Max M. and Margolskee RF. (2002). A transient receptor potential channel expressed in taste receptor cells. Nature Neurosci. 5(11):1169-76.
6. Mirshahi T, Mittal , Zhang H, Linder ME, Logothetis DE. (2002) Distinct sites on G protein beta gamma subunits regulate different effector functions. J Biol Chem 277(39):36345-50.
7. He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE (2002) Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel actiity through interactions with the beta gamma subunits of G proteins. J Biol Chem 277:6088-96
8. Mirshahi T, Robillard L, Zhang H, Hebert TE, Logothetis DE (2002) Gbeta residues that do not interact with Galpha underlie agonist-independent actiity of K+ channels. J Biol Chem 277(9):7348-55
9. Rohac T., Lopes CMB., Mirshahi T., Jin T., Zhang H. & Logothetis DE. (2001). Assay pf phosphatidylinositol biphosphate regulation of potassium channels. In G protein pathways, part C: Effector mechanism. Methods in Enzymology, 345-357
10. Hughes TE, Zhang, HL, Logothetis DE, Berlot CH (2001). isualization of a functional Gaq-green fluorescent protein fusion in liing cells: Association with the plasma membrane is disrupted by mutational actiation and by elimination of palmitoylation sites, but not by actiation mediated by receptors or AlF4- . J Biol Chem, 276:4227-4235.
11. Kobrinsky E, Mirshahi T, Zhang H, Jin T, Logothetis DE (2000). Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization. Nature Cell Biology, 2:507-14.
12. Zhang,HL., He C., Yan XX, Mirshahi T and Logothetis DE. (1999) Actiation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nature Cell Biology, 1:183-188
13. He, C., Zhang, HL., Mirshahi, T. and Logothetis, D. (1999). Specific Gbg Interaction With a K+ Channel Distinguish Between Basal and Agonist-induced Currents. J. Bio. Chem, 274:12517-12524
14. Logothetis, E.D. & Zhang, HL. (1999) Gating of G protein-sensitie inwardly rectifying K+ channels through phosphatidylinositol 4,5-bisphosphate-dependent mechanism. J. Physiol. London, 520, 630
15. Zhang, H-L., T. B. Bolton, A. E. Piekarska & G. A. McPherson (1998). The electrophysiological effects of tetraphenylphosphonium and tetraphylboron on ascular somooth muscle. Eur. J. Pharmacol, 347(1), 119-23
16. Zhang, H-L & Bolton, T. B. (1996) ATP-sensitie potassium channels and their modulation by nucleotides and potassium channel openers in ascular smooth muscle cells. In: Smooth muscle excitation. Eds: Bolton T. B. & Tomita, T. Academic Press Limited. Chapter 12, pp 139-154
17. Zhang, H-L. & Bolton, T. B. (1996). Two types of ATP-sensitie potassium channels in rat portal ein smooth muscle cells. Br. J. Pharmacol. 118, 105-114
18. Zhang, H-L. & Bolton, T. B. (1995). Effects of UK-84149 on oltage-actiated calcium currents of single smooth muscle cells from guinea-pig and rabbit jejunum and rabbit coronary. Br. J. Pharmacol., 114, 1657-1665
19. Zhang, H-L. & Bolton, T. B. (1995). Actiation by Intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitie K-channel in smoothmuscle cells of rat mesenteric artery. Br. J. Pharmacol., 114, 662-672
20. Beech, D.J., Zhang, H., Nakao, K. & Bolton, T.B. (1993). Single channel and whole-cell K-currents eoked by lecromakalim in smooth muscle cells from the rabbit portal ein. Br. J. Pharmacol., 110, 583-590.
21. Beech, D.J., Zhang, H., Nakao, K. & Bolton, T.B. (1993). K channel actiation by nucleotide diphosphates and its inhibition by glibenclamide in ascular smooth muscle cells. Br. J. Pharmacol., 110, 573-582

A text book of fundamental medical pharmacology (英文)，編委，吉林科學(xué)技術(shù)出版社， 2004

1. 國(guó)家杰出青年科學(xué)基金 (30325038), 2004.1-2007.12
2. 美國(guó)國(guó)家衛(wèi)生研究院NIH Fogarty 國(guó)際合作項(xiàng)目(1 R03 TW006020-01A1): Protein Kinase C-dependent inhibition of Kir channels, 2003.4-2006.4，
3. 科技部基礎(chǔ)研究重大項(xiàng)目前期研究專(zhuān)項(xiàng)(2003CCA00300):細(xì)胞膜磷脂對(duì)離子通道功能的調(diào)節(jié)及其生理學(xué)意義, 2003.12-2005.12
4. 國(guó)家自然科學(xué)基金項(xiàng)目(30270361): 膜磷脂PIP2對(duì)M電流及KCNQ電流的調(diào)節(jié)作用. 2003.1-2005.12，
5. 河北省自然科學(xué)基金項(xiàng)目。磷脂酰肌醇二磷酸對(duì)M電流的調(diào)節(jié)及生理學(xué)意義（303464），2003.1-2005.12
6. 國(guó)家自然科學(xué)基金項(xiàng)目(30240001): 老年大鼠M電流的研究. 2002.1---2002.12,
7. 教育部科學(xué)技術(shù)研究重點(diǎn)項(xiàng)目(02016): pH調(diào)節(jié)內(nèi)向整流鉀離子通道功能的分子機(jī)制, 2002.1-2003.12

獲得榮譽(yù)

國(guó)家杰出青年科學(xué)基金獲得者，燕趙學(xué)者，中國(guó)僑聯(lián)特聘專(zhuān)家，河北省省管專(zhuān)家，獲中國(guó)僑聯(lián)科技創(chuàng)新人才獎(jiǎng)。^[3]獲河北省十大科技杰出青年，享受?chē)?guó)務(wù)院政府特殊津貼，河北省強(qiáng)勢(shì)學(xué)科（藥理學(xué)）帶頭人，省管優(yōu)秀專(zhuān)家。^[2]