人物經(jīng)歷
2003年畢業(yè)于天津師范大學(xué)，獲得碩士學(xué)位。
2006年畢業(yè)于南開(kāi)大學(xué)，獲得博士學(xué)位。
同年畢業(yè)留高分子所工作至今。
目前還擔(dān)任Biomacromolecules, Molecular Pharmaceutics, Nanomedicine-UK, International Journal of Pharmaceutics, Carbohydrate Polymers, Carbohydrate Research, Journal of Biomaterials Science, polymer Edition, Drug News and Perspectives, European Journal of Chemistry, Asian Journal of Pharmaceutics, Current Drug Delivery等國(guó)際期刊審稿人。
研究方向
生物醫(yī)用高分子研究、藥物傳遞、細(xì)胞支架的設(shè)計(jì)與合成、智能高分子材料研究；
具有特殊鏈構(gòu)造的非線型生物高分子設(shè)計(jì)與合成；
基于多肽、多糖和生物可降解性高分子的生物醫(yī)用材料；
光、磁、熱、糖和 pH 響應(yīng)性環(huán)境敏感智能材料；
藥物緩釋、控釋及生物活性物質(zhì)傳輸?shù)妮d體材料；
環(huán)境響應(yīng)性無(wú)機(jī)/有機(jī)雜化納米材料；
抗菌高分子材料；
主要貢獻(xiàn)
研究成果發(fā)表在Biomaterials，Journal of Controlled Release, Biomacromolecules，Acta Biomaterialia，Polymer，European Journal of Pharmaceutics and Biopharmaceutics，New Journal of Chemistry，Carbohydrate Polymers, Journal of Colloid and Interface Science等期刊上，共發(fā)表SCI論文30余篇。
科研項(xiàng)目
1.天津市自然科學(xué)基金：生物大分子藥物黏膜智能化給藥的納米載體材料研究（已結(jié)題）；
2.國(guó)家自然科學(xué)基金：新型含生物黏附性和酶抑制活性兩親性高分子藥物載體材料的研究（2009.1-2011.12）；
3.教育部博士點(diǎn)基金：新型鼻腔給藥載體材料的研究（2009.1-2011.12）；
4.國(guó)家自然科學(xué)基金：用于銅綠假單胞菌識(shí)別拓?fù)渖锔叻肿拥臉?gòu)建及其與蛋白質(zhì)相互作用研究（2012.1-2015.12）；
研究成果
1.Xuejiao Zhang, Xinge Zhang*, Zhongming Wu, Xiujun Gao, Cui Cheng, Chaoxing Li, Zhen Wang. A novel hydrotropic β-cyclodextrin grafted hyperbranched polyglycerol copolymer for hydrophobic drug delivery. Acta Biomaterialia 2011, 7:585-592.
2. Xuejiao Zhang, Xinge Zhang*, Zhongming Wu, Xiujun Gao, Cui Cheng, Chaoxing Li*,Zhen Wang. β-Cyclodextrin grafted hyperbranched polyglycerols as carriers for nasal insulin delivery. Carbohydrate Polymers 2011, 84:1419-1425.
3.Shujun Shu, Xinge Zhang*, Zhongming Wu, Zhen Wang, Chaoxing Li*. Gradient cross-linked biodegradable polyelectrolyte nanocapsules for intracellular protein drug delivery. Biomaterials 2010, 31(23):6039-6049.
4.Teng Dayong, Wu Zhongming, Zhang Xinge*, Zhang shaomin, Zheng Chao, Wang Zhen, Li Chaoxing*. Synthesis and characterization of in situ cross-linked hydrogel based on self-assembly of thiol-modified chitosan with PEG diacrylate using Michael type addition. Polymer 2010, 51:639-646.
5.Shujun Shu, Chunyang Sun, Xinge Zhang*, Zhongming Wu, Zhen Wang, Chaoxing Li*. Hollow and degradable polyelectrolyte nanocapsules for protein drug delivery. Acta Biomaterialia 2010, 6:210-217.
6.Xiujun Gao, Xinge Zhang*, Zhongming Wu, Xuejiao Zhang, Zhen Wang, Chaoxing Li*. Synthesis and physicochemical characterization of a novel amphiphilic polylactic acid-hyperbranched polyglycerol conjugate for protein drug delivery. Journal of Controlled Release 2009, 140:141-147.
7.Shujun Shu, Xin Wang, Xinge Zhang*, Zhen Wang, Chaoxing Li*. Disulfide cross-linked biodegradable polyelectrolyte nanoparticles as oral protein drugs delivery. New Journal of Chemistry 2009, 33:1882-1887.
8.Xingju Jin, Xinge Zhang*, Zhongmin Wu, Dayong Teng, Xuejiao Zhang, Yanxia Wang, Zhen Wang, Chaoxing Li*. Amphiphilic random glycopolymer based on phenylboronic acid: Synthesis, characterization, and potential as glucose-sensitive matrix. Biomacromolecules 2009, 10:1337-1345.
9.Xinge Zhang*,Zhongming Wu, Xiujun Gao, Shujun Shu, Huijie Zhang, Zhen Wang, Chaoxing Li. Chitosan bearing pendant cyclodextrin as a carrier for controlled protein release. Carbohydrate Polymers 2009, 77:394-401.
10.Dayong Teng, Jingli Hou, Xinge Zhang*, Xin Wang, Zhen Wang, Chaoxing Li*. Glucosamine-carrying temperature- and pH-sensitive microgels: preparation, characterization and in vitro drug release studies. Journal of Colloid and Interface Science 2008, 322: 333-341.
11.Xinge Zhang, Huijie Zhang, Zhongming Wu, Zhen Wang, Haimei Niu, Chaoxing Li. Nasal absorption enhancement of insulin by using PEG-g-chitosan nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics 2008, 68(3):526-534.
