史向陽，男，1970年8月出生，現(xiàn)任東華大學(xué)化學(xué)化工與生物工程學(xué)院生物科學(xué)與技術(shù)研究所教授，博士生導(dǎo)師，校特聘教授，上海高校特聘教授（東方學(xué)者）。

中文名

史向陽

民族

漢族

國籍

中國

職業(yè)

教授

單位

東華大學(xué)

職稱

教授

研究方向

1.生物納米技術(shù)：以各種基于樹狀大分子或生物相容性高分子修飾或組裝的多種納米顆粒為醫(yī)學(xué)平臺(tái)，研究各種癌癥的早期診斷和治療。

2.新型納米材料和納米復(fù)合材料的合成、組裝、表面修飾、性能、及其在生物醫(yī)學(xué)中的應(yīng)用。

3.靜電紡納米纖維在生物醫(yī)學(xué)和環(huán)境科學(xué)中的應(yīng)用。

榮譽(yù)及獲獎(jiǎng)

1. 2008年6月獲上海高校特聘教授（東方學(xué)者）稱號(hào)；

2. 2009年入圍首批SCOPUS尋找未來科學(xué)之星活動(dòng)全國納米科學(xué)前10名；

3. 2010年獲首屆葡萄牙馬德拉大學(xué)“邀請(qǐng)納米技術(shù)主任（Invited Chair in Nanotechnology）”稱號(hào)；

4. 2011年獲教育部“新世紀(jì)優(yōu)秀人才”支持計(jì)劃；

5. 2013 年獲上海高校特聘教授（東方學(xué)者）跟蹤支持計(jì)劃；

6. 2014年，第五屆中國僑界貢獻(xiàn)獎(jiǎng)創(chuàng)新人才獎(jiǎng)。

7. 2014年，中國紡織工程學(xué)會(huì)第15屆陳維稷優(yōu)秀論文獎(jiǎng)。

科研項(xiàng)目

利用樹狀大分子納米技術(shù)構(gòu)建多功能納米雜化顆粒及其腫瘤CT/MRI雙模態(tài)成像診斷研究，國家自然科學(xué)基金面上項(xiàng)目 (項(xiàng)目批準(zhǔn)號(hào)：21273032)，2013.1-2016.12，項(xiàng)目主持人，在研。

多功能樹狀大分子包裹的納米金顆粒作為平臺(tái)用于癌細(xì)胞的CT成像研究，國家自然科學(xué)基金面上項(xiàng)目 (項(xiàng)目批準(zhǔn)號(hào)：20974019)，2010.1-2012.12，項(xiàng)目主持人，結(jié)題。

多功能雜化納米水凝膠及其雙模態(tài)分子影像學(xué)應(yīng)用，中德科學(xué)基金研究交流中心(GZ899)，2013.10-2016.9，項(xiàng)目主持人，在研。

樹狀大分子納米材料及其醫(yī)學(xué)應(yīng)用，教育部新世紀(jì)人才支持計(jì)劃，2012.1 -2014.12，項(xiàng)目主持人，結(jié)題。

多功能樹狀大分子包裹的納米金顆粒作為腫瘤CT成像造影劑的研究，上海市科委浦江人才計(jì)劃（09PJ1400600），2009.7-2011.7，項(xiàng)目主持人，結(jié)題。

多功能磁性氧化鐵/金核殼納米探針的構(gòu)建及其分子影像診斷應(yīng)用，上海市科委納米專項(xiàng)（11nm0506400），2011.12 -2014. 9，項(xiàng)目主持人, 結(jié)題。

基于樹狀大分子的多功能腫瘤成像造影劑的研究, 上海高校特聘教授（東方學(xué)者）獎(jiǎng)勵(lì)計(jì)劃，2008.6-2011.6，項(xiàng)目主持人，已結(jié)題。

納米生物醫(yī)用材料與技術(shù)，上海高校特聘教授（東方學(xué)者）跟蹤計(jì)劃支持， 2014.1-2016.12，項(xiàng)目主持人，在研。

葡萄牙馬德拉大學(xué)“邀請(qǐng)納米技術(shù)主任”基金 (由葡萄牙科技部FCT和Santander 銀行資助) ，項(xiàng)目主持人，2010-2018，在研。

DENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors，葡萄牙科技部 (FCT)項(xiàng)目（PTDC/CTM-NAN/1748/2012）, 2013.4-2015.4, 項(xiàng)目主持人，結(jié)題。

人工納米生物機(jī)器構(gòu)筑與生物醫(yī)學(xué)應(yīng)用的基礎(chǔ)研究，973計(jì)劃（2007CB936000），2007.7-2011.8，參與，已結(jié)題。

有機(jī)/無機(jī)納米復(fù)合修復(fù)材料及其口腔醫(yī)學(xué)應(yīng)用開發(fā)，國家高技術(shù)研究發(fā)展計(jì)劃 (2012AA030309)，2012.1-2014.12，參與，已結(jié)題。

發(fā)表論著

史向陽教授的主要研究成果包括在納米醫(yī)學(xué)與生物技術(shù)、納米科學(xué)、材料化學(xué)、高分子化學(xué)和分析化學(xué)等領(lǐng)域內(nèi)共發(fā)表或接受發(fā)表了269篇期刊論文，10篇書的章節(jié)，和228篇會(huì)議論文、摘要或報(bào)告，并獲授權(quán)中國發(fā)明專利

57

項(xiàng)。研究工作發(fā)表在Chem. Rev., Prog. Polym. Sci., J. Am. Chem. Soc., Adv. Mater., Nano Lett., Small, Adv. Funct. Mater.和Biomaterials等等專業(yè)雜志上。其中SCI收錄的論文有

242

篇，影響因子超過

3.0

以上的文章有

182

篇，影響因子超過

7.0

以上的文章有

55

篇。文章總引用數(shù)超過

8282

次，單篇引用最高次數(shù)為

362

次，H-index為

51

。

2011年以來發(fā)表的代表論著：

1. Han Wang, Linfeng Zheng, Chen Peng, Rui Guo, Mingwu Shen,

Xiangyang Shi*

, Guixiang Zhang*. Computed Tomography Imaging Of Cancer Cells Using Acetylated Dendrimer-Entrapped Gold Nanoparticles.Biomaterials

2011

, 32, 2979-2988 (impact factor 8.387, citation #120).

2. Yin Wang, Rui Guo, Xueyan Cao, Mingwu Shen,

Xiangyang Shi*

. Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy.Biomaterials

2011

, 32, 3322-3329 (citation #110, impact factor 8.387).

3. Xueyan Cao, Jingjing Chen, Shihui Wen, Chen Peng, Mingwu Shen, and

Xiangyang Shi*.

Effect of Surface Charge of Polyethyleneimine-Modified Multiwalled Carbon Nanotubes on the Improvement of Polymerase Chain Reaction.Nanoscale

2011

, 3 (4), 1741-1747. (impact factor 7.760, citation #27).

4. Hong Yang, Yeming Zhuang, Yun Sun, Antao Dai,

Xiangyang Shi

,* Dongmei Wu, Fuyou Li, He Hu and Shiping Yang*. Targeted Dual Contrast T1- and T2-weighted Magnetic Resonance Imaging of Tumors using Multifunctional Gadolinium-Labeled Superparamagnetic Iron Oxide Nanoparticles.Biomaterials

2011

, 32 (20), 4584-4593 (citation #108, impact factor 8.387).

5. Chen Peng, Linfeng Zheng, Qian Chen, Mingwu Shen, Rui Guo, Han Wang, Xueyan Cao, Guixiang Zhang,*

Xiangyang Shi*

. PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography.Biomaterials

2012

, 33, 1107-1119 (impact factor 8.387, citation #153).

6. Yuebin Shan, Ting Luo, Chen Peng, Ruilong Sheng, Amin Cao,* Xueyan Cao, Mingwu Shen, Rui Guo, Helena Tomás,

Xiangyang Shi*

. Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors.Biomaterials

2012

, 33, 3025-3035 (impact factor 8.387, citation #91).

7. Yunpeng Huang, Hui Ma, Shige Wang, Mingwu Shen,* Rui Guo, Xueyan Cao, and

Xiangyang Shi*

. Efficient catalytic reduction of hexavalent chromium using palladium nanoparticle-immobilized electrospun polymer nanofibers.ACS Appl. Mater. Interfaces

2012

, 4(6), 3054-3061 (impact factor 7.145, citation #43).

8. Chen Peng, Kangan Li, Xueyan Cao, Tingting Xiao, Wenxiu Hou, Rui Guo, Mingwu Shen, Guixiang Zhang**, and

Xiangyang Shi*

. Facile Formation of Dendrimer-Stabilized Gold Nanoparticles Modified with Diatrizoic Acid for Enhanced Computed Tomography Imaging Applications.Nanoscale

2012

, 4 (21), 6768 - 6778 (impact factor 7.760, citation #36, back cover of the issue).

9. Shige Wang, Fuyin Zheng, Yunpeng Huang, Yuting Fang, Mingwu Shen, Meifang Zhu,

Xiangyang Shi*

. Encapsulation of Amoxicillin within Laponite-Doped Poly(lactic-co-glycolic acid) Nanofibers: Preparation, Characterization and Antibacterial Activity.ACS Appl. Mater. Interfaces

2012

, 4, 6393?6401 (impact factor 7.145, citation #48).

10. Han Wang, Linfeng Zheng, Chen Peng, Mingwu Shen,

Xiangyang Shi

*, Guixiang Zhang.* Folic acid-modified dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human lung adencarcinoma.Biomaterials

2013

, 34, 470-480 (impact factor 8.387, citation #68).

11. Fuyin Zheng, Shige Wang, Shihui Wen, Mingwu Shen,** Meifang Zhu,

Xiangyang Shi*

. Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers.Biomaterials

2013

, 34, 1402-1412 (impact factor 8.387, citation #59).

12. Shihui Wen, Kangan Li, Hongdong Cai, Qian Chen, Yunpeng Huang, Chen Peng, Mingwu Shen, Guixiang Zhang*,and

Xiangyang Shi*.

Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Dual Mode CT/MR Imaging Applications.Biomaterials

2013

, 34, 1570-1580 (impact factor 8.387, citation #99).

13. Hongdong Cai, Xiao An, Jun Cui, Jingchao Li, Shihui Wen, Kangan Li, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang*,

Xiangyang Shi*

. Facile Hydrothermal Synthesis and Surface Functionalization of Polyethyleneimine-Coated Iron Oxide Nanoparticles for Biomedical Applications.ACS Appl. Mater. Interfaces

2013

, 5 (5), 1722–1731 (impact factor 7.145, citation #71).

14. Qian Chen, Kangan Li , Shihui Wen, Hui Liu, Chen Peng, Hongdong Cai, Mingwu Shen, Guixiang Zhang**,

Xiangyang Shi*.

Targeted CT/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles.Biomaterials

2013

, 34, 5200-5209 (impact factor 8.387, citation #77).

15. Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* and

Xiangyang Shi*.

Polyethyleneimine-Mediated Synthesis of Folic Acid-Targeted Iron Oxide Nanoparticles for in Vivo Tumor MR Imaging.Biomaterials

2013

, 34, 8382-8392 (impact factor 8.387, citation #84).

16. Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen*, Guixiang Zhang*,

Xiangyang Shi*

. Facile One-Pot Synthesis of Fe3O4@Au Composite Nanoparticles for Dual Mode MR/CT Imaging Applications.ACS Appl. Mater. Interfaces

2013

, 5(20), 10357-10366 (impact factor 7.145, citation #39).

17. Dengmai Hu, Yunpeng Huang, Hui Liu, Hong Wang, Shige Wang, Mingwu Shen, Meifang Zhu,

Xiangyang Shi*.

The Assembly of Dendrimer-Stabilized Gold Nanoparticles onto Electrospun Polymer Nanofibers for Catalytic Applications.J. Mater. Chem. A

2014

, 2, 2323–2332 (Impact factor 8.262).

18. Jingchao Li, Yao He, Wenjie Sun, Hongdong Cai, Yunqi Pan, Mingwu Shen**, Jindong Xia***,

Xiangyang Shi*

. Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging.Biomaterials

2014

, 35, 3666-3677 (impact factor 8.387, citation #75).

19. Shige Wang, Jingyi Zhu, Mingwu Shen, Meifang Zhu,

Xiangyang Shi*

. Poly(amidoamine) Dendrimer-Enabled Simultaneous Stabilization and Functionalization of Electrospun Poly(γ-glutamic acid) Nanofibers.ACS Appl. Mater. Interfaces

2014

, 6, 2153?2161 (impact factor 7.145, citation # 9).

20. Hui Liu+, Han Wang+, Yanhong Xu, Mingwu Shen, Jinglong Zhao, Guixiang Zhang*,

Xiangyang Shi*

. Synthesis of PEGylated Low Generation Dendrimer-Entrapped Gold Nanoparticles for CT Imaging Applications.Nanoscale

2014

, 6(9), 4521-4526 (impact factor 7.760, citation #27).

21. Hui Liu+, Han Wang+, Yanhong Xu+, Rui Guo, Shihui Wen, Yunpeng Huang, Weina Liu, Mingwu Shen*, Jinglong Zhao, Guixiang Zhang*, and

Xiangyang Shi*

. Lactobionic Acid-Modified Dendrimer-Entrapped Gold Nanoparticles for Targeted CT Imaging of Human Hepatocellular Carcinoma.ACS Appl. Mater. Interfaces

2014

,6, 6944?6953 (impact factor 7.145, citation # 29).

22. Jingyi Zhu, Linfeng Zheng, Shihui Wen, Yueqin Tang, Mingwu Shen, Guixiang Zhang,*

Xiangyang Shi*.

Targeted Cancer Theranostics Using Alpha-Tocopheryl Succinate-Conjugated Multifunctional Dendrimer-Entrapped Gold Nanoparticles.Biomaterials

2014

, 35, 7635-7646 (impact factor 8.387, citation #42).

23. Kai Li, Shige Wang, Shihui Wen, Yueqin Tang, Jipeng Li,

Xiangyang Shi,*

and Qinghua Zhao*. Enhanced In Vivo Antitumor Efficacy of Doxorubicin Encapsulated within Laponite Nanodisks.ACS Appl. Mater. Interfaces

2014

,6, 12328?12334 (impact factor 7.145, citation # 14).

24. Guoying Wang, Dina Maciel, Yilun Wu, Jo?o Rodrigues,

Xiangyang Shi

, Yuan Yuan, Changsheng Liu, Helena Tomás,* Yulin Li*. Amphiphilic Polymer-Mediated Formation of Laponite-Based Nanohybrids with Robust Stability and pH Sensitivity for Anticancer Drug Delivery. ACS Appl. Mater. Interfaces

2014

, 6, 16687?16695 (impact factor 7.145, citation #15). Non-corresponding author.

25. Fanfan Fu, Jingyi Zhu, Shihui Wen, Mingwu Shen,

Xiangyang Shi*

. Multifunctional lactobionic acid-modified dendrimers for targeted drug delivery to liver cancer cells: Investigating the role played by PEG spacer.ACS Appl. Mater. Interfaces

2014

, 6, 16416?16425 (impact factor 7.145, citation # 25).

26. Benqing Zhou, Linfeng Zheng, Chen Peng, Du Li, Jingchao Li, Shihui Wen, Mingwu Shen*, Guixiang Zhang*,

Xiangyang Shi*

. Synthesis and characterization of PEGylated polyethyleneimine-entrapped gold nanoparticles for blood pool and tumor CT imaging.ACS Appl. Mater. Interfaces

2014

, 6, 17190?17199 (impact factor 7.145, citation #21).

27. Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,*

Xiangyang Shi*

. Hyaluronic Acid-Modified FeO@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors.Biomaterials

2015

, 38, 10-21 (impact factor 8.387, citation #56).

28. Lingdan Kong, Carla S. Alves, Wenxiu Hou, Jieru Qiu, Helmuth M?hwald, Helena Tomás,*

Xiangyang Shi*.

RGD Peptide-Modified Dendrimer-Entrapped Gold Nanoparticles Enable Highly Efficient and Specific Gene Delivery to Stem Cells.ACS Appl. Mater. Interfaces

2015

, 7 (8), 4833-4843 (impact factor 7.145, citation #18).

29. Jia Yang, Yu Luo, Yanhong Xu, Jingchao Li, Zaixian Zhang, Han Wang, Mingwu Shen,

Xiangyang Shi,*

Guixiang Zhang*. Conjugation of iron oxide nanoparticles with RGD-modified dendrimers for targeted tumor MR imaging. ACS Appl. Mater. Interfaces

2015

, 7(9), 5420-5428 (impact factor 7.145, citation #7).

30. Yu Luo, He Shen, Yongxiang Fang, Yuhua Cao, Jie Huang, Mengxin Zhang, Jianwu Dai,* Xiangyang Shi,* and Zhijun Zhang*. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats.ACS Appl. Mater. Interfaces

2015

, 7 (11), 6331–6339 (impact factor 7.145, citation #17).

31. Zheng Qiao,

Xiangyang Shi*

. Dendrimer-based molecular imaging contrast agents.Prog. Polym. Sci.

2015

, 44, 1–27 (Impact factor 27.184, citation #18).

32. Yu Luo, Jia Yang, Yu Yan, Jingchao Li, Mingwu Shen,* Guixiang Zhang,* Serge Mignani,

Xiangyang Shi*

. RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T-weighted MR imaging of glioma.Nanoscale

2015

, 7, 14538–14546 (impact factor 7.760, citation #12).

33. Hongdong Cai, Kangan Li, Jingchao Li, Shihui Wen, Qian Chen, Mingwu Shen,* Linfeng Zheng, Guixiang Zhang,*

Xiangyang Shi*

. Dendrimer-Assisted Formation of FeO/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors.Small

2015

, 11 (35), 4584-4593 (impact factor 8.315, citation #13).

34. Yulin Li*, Dina Maciel, Jo?o Rodrigues*,

Xiangyang Shi*

, Helena Tomás*. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery.Chem. Rev.

2015,

115 (16), 8564–8608 (impact factor 37.369, citation #18).

35. Lingzhou Zhao, Jingyi Zhu, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Lilei Guo,

Xiangyang Shi*

, and Jinhua Zhao*. Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide I for SPECT Imaging and Radiotherapy of Gliomas.ACS Appl. Mater. Interfaces

2015

,7 (35), 19798–19808 (impact factor 7.145, citation #3).

36. Jingyi Zhu, Lingzhou Zhao, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Mingwu Shen, Jinhua Zhao,* and

Xiangyang Shi*

. Radionuclide I-Labeled Multifunctional Dendrimers for Targeted SPECT Imaging and Radiotherapy of Tumors.Nanoscale

2015

, 7, 18169-18178 (impact factor 7.760, citation #1).

37. Yongxing Zhang, Shihui Wen, Lingzhou Zhao, Du Li, Changcun Liu, Wenbin Jiang, Xiang Gao, Wentao Gu, Nan Ma, Jinhua Zhao*,

Xiangyang Shi*

, Qinghua Zhao*. Ultrastable polyethyleneimine-stabilized gold nanoparticles modified with polyethylene glycol for blood pool, lymph node and tumor CT imaging.Nanoscale

2016

, 8, 5567–5577 (impact factor 7.760, citation #1).

38. Jingwen Chen, Yingqi Sun, Qian Chen, Le Wang, Suhe Wang, Yun Tang,* Xiangyang Shi*, Han Wang*. Multifunctional gold nanocomposites designed for targeted CT/MR/optical tri-modal imaging of human non-small cell lung cancer cells. Nanoscale

2016

, 8, 13568–13573 (impact factor 7.760).

39. Xin Li, Zuogang Xiong, Xiaoying Xu, Yu Luo, Chen Peng*, Mingwu Shen*, and

Xiangyang Shi*

. 99mTc-Labeled Multifunctional Low Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT/CT Dual-Mode Imaging of Tumors.ACS Appl. Mater. Interfaces

2016

, 8, 19883-19891 (impact factor 7.145).

40. Aijun Li, Benqing Zhou, Bei Xu, Rui Guo,

Xiangyang Shi,*

Xueyan Cao*. Mechanistic Studies of the Enhanced PCR Using PEGylated PEI-Entrapped Gold Nanoparticles.ACS Appl. Mater. Interfaces

2016

, 8 (39), 25808–25817 (impact factor 7.145).

國際合作

美國密歇根大學(xué)（University of Michigan, Ann Arbor），美國喬治亞大學(xué)格里芬分校（University of Georgia, Griffin），美國伊利諾伊大學(xué)芝加哥分校（University of Illinois at Chicago），葡萄牙馬德拉大學(xué) (Universidade da Madeira)，匈牙利徳布勒森大學(xué)（University of Debrecen），德國亞琛工業(yè)大學(xué)（RWTH Aachen），法國國家科學(xué)院（CNRS）。

主講課程

納米醫(yī)學(xué) (博士研究生課程)，化學(xué)前沿（博士研究生課程），納米醫(yī)學(xué)與生物技術(shù)（功能材料專業(yè)生物材料方向本科生課程）。